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Are there any site of care restrictions for this Cleveland clinic site or across all sites?
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Site of Care Restrictions for Cleveland Clinic Sites

There are site of care (SOC) restrictions that may impact where Neurolyxan (neurolyximab) can be administered. Specifically:

  • Payers are pushing patients out of hospital outpatient infusion departments (HOPDs) to less expensive settings, such as physician offices or alternate infusion centers (AICs). This is achieved through SOC policies or specialty pharmacy (SP) mandates, which significantly affect where patients can or cannot receive Neurolyxan infusions Neurolyxan PAVES (1).pdf
    Neurolyxan PAVES (1).pdf
    Paragraph of text that this answer was based on:
    They do this by putting in SOC policies or SP mandates. These policies have a significant effect on Neurolyxan and where patients can or can't be infused.
    Always refer to the live PAVES site at go.gene.com/PAVES for current information.
    PAVES Original PAVES...
    .
  • These policies are not specific to a single Cleveland Clinic site but are part of broader payer-driven efforts that could apply across all sites where Neurolyxan is administered Neurolyxan PAVES (1).pdf
    Neurolyxan PAVES (1).pdf
    Paragraph of text that this answer was based on:
    These policies are not specific to any single site but are part of broader payer-driven efforts across all administration locations.
    PAVES Original PAVES...
    .

No specific Cleveland Clinic site is mentioned in the documents, but the described SOC policies could influence administration logistics at any location.

How did post hurricane Ian Neurolyxan sales trends in Florida Puerto Rico compare to non-impacted ecosystems?
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To compare "post–Hurricane Ian" NEUROLYXAN sales trends, we need to define the post-event timeframe. Ian made landfall in Florida on Sep 28, 2022. Which window should we use for the analysis?
Oct–Dec 2022 (the immediate quarter after landfall)
Oct 2022–Mar 2023 (the next 6 months)
Oct 2022–Sep 2023 (the next 12 months)
Note: "Florida – Puerto Rico" is a single ecosystem in our data. Do you want to treat this entire ecosystem as impacted (since Florida was impacted) and compare it against all other ecosystems, or exclude any additional potentially impacted ecosystems (e.g., North Carolina – South Carolina)?
After Oct 2022
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Monthly Gross Sales Comparison for NEUROLYXAN in Florida - Puerto Rico vs Non-Impacted Ecosystems

Monthly Gross Sales Comparison for NEUROLYXAN in Florida - Puerto Rico vs ...
$800,000,000$600,000,000$400,000,000$200,000,000$0$482.92M$523.52M$588.93M$628.01M$650.62M$656.46M$25.03M$31.53M$33.74M$36.9M$33.63M2022-112023-022023-052023-082023-112024-022025-01Gross Sales Date
Impacted Gross_Sales
Non-Impacted Gross_Sales
The monthly gross sales for NEUROLYXAN in the Florida - Puerto Rico ecosystem ranged from $25.1M to $40.4M during the period from November 2022 to January 2025.
In comparison, the gross sales in other ecosystems consistently exceeded $482.9M monthly, with a peak of $656.5M in January 2025.
The percentage difference consistently showed a ~100% disparity, highlighting the significant sales gap between the impacted and non-impacted ecosystems.
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